Jozwik KM, Held JP, Hecht CA & Patel MR. (2024). A viable hypomorphic mutation in the mitochondrial ribosome subunit, MRPS-31, exhibits mitochondrial dysfunction in C. elegans. microPublication Biology.
Gitschlag BL, Pereira CV, Held JP & Patel MR. (2024). Multilevel selection analysis reveals diversity in selfish mitochondrial genome dynamics. Nature Communications. 15(1): 8237. PMID 39300074.
Maxwell CA, Grubbs B, Dietrich MS, Boon JT, Dunavan J, Knickerbocker KJ, & Patel MR. (2024). MitoFit: Evaluation of a mitochondrial fitness science communication intervention for aging adults. MedRxiv.
Held JP & Patel MR. (2024). RNA: Desilencing to the rescue. Current Biology. PMID: 38889679.
Held JP, Dbouk NH, Strozak AM, Grub LK, Ryou H, Schaffner SH, & Patel MR. (2024). Germline status and micronutrient availability regulate somatic mitochondrial quality control pathway. BioRxiv. In revision, Developmental Cell.
Grub LK*, Held JP*, Hansen TJ, Schaffner SH, Canter MR^, Malagise EM & Patel MR. (2023). A role for N6-methyldeoxyadenosine in C. elegans mitochondrial genome regulation. BioRxiv. *Equal contributors. ^Undergraduate author.
Tsyba N, Feng G, Grub LK, Held JP, Strozak AM, Burkewitz K & Patel MR. (2023). Tissue-specific heteroplasmy segregation is accompanied by a sharp mtDNA decline in Caernorhabditis elegans soma. iScience 26(4):106349. PMID 36968071
Grub LK, Tsyba N & Patel MR. (2022). Should I stay, or should I go? Gene retention in organellar genomes. Cell Systems 13: 861-863. PMID 36395725
Schwartz AZA, Tsyba N, Abdu Y, Patel MR & Nance J. (2022). Independent regulation of mtDNA quantity and quality resets the mitochondrial genome in C. elegans primordial germ cells. eLife 11: e80396. PMID 36200990
Maxwell CA, Roberts C, Oesmann K, Muhimpundu S, Archer KR, Patel MR, Mulubrhan MF, Muchira J, Boon J & LaNoue M. (2022). Health and wellness for disadvantaged older adults: The AFRESH pilot study. PEC Innovation
Schaffner SH & Patel MR. (2022). Plant organellar genomes utilize gene conversion to drive heteroplasmic sorting. PNAS 119(37):e2213014119. PMID 36044538
Held JP, Feng G, Saunders BR, Pereira CV, Burkewitz K, & Patel MR. (2022). A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. eLife 11: e71634. PMID 35451962
Pereira CV, Gitschlag BL & Patel MR. (2021). Cellular mechanisms of mtDNA heteroplasmy dynamics. Critical Rev Biochem Mol Biol 13: 1-16. PMID 34120542
Kirby CS & Patel MR. (2021). Elevated mitochondrial DNA copy number found in ubiquinone-deficient clk-1 mutants is not rescued by ubiquinone precursor 2-4-dihydroxybenzoate. Mitochondrion 58: 38-48. PMID 33581333
Gitschlag BL, Tate AT & Patel MR. (2020). Nutrient status shapes selfish mitochondrial genome dynamics across different levels of selection. eLife 9: e56686 PMID 32959778
Previewed by Camus MF. (2020). Perils of Cheating. eLife 9: e62222. PMID 32959780
Held JP & Patel MR. (2020). Functional conservation of mitochondrial RNA levels despite divergent mtDNA organization. BMC Res Notes 13: 334. PMID 32653018
Gitschlag BL & Patel MR. (2019). Mitochondria: A Microcosm of Darwinian Competition. Current Biology 29: PR1316-R1318. PMID 31846681
Patel MR. (2017). Inheritance: Male mtDNA just can’t catch a break. Current Biology 27: R259–R281 PMID 28376332
Gitschlag BL, Kirby CS, Samuels,DC Gangula RD, Mallal SA & Patel MR. (2016). Homeostatic responses regulates selfish mitochondrial genome dynamics in C. elegans. Cell Metabolism 24: 91-103 PMID 27411011
Previewed by Picard M, Vincent AE & Turnbull DM. (2016). Expanding our understanding of mtDNA deletions. Cell Metabolism 94: 3-4 PMID 27411002
Postdoctoral and graduate work
Patel MR, Miriyala GK, Littleton AJ, Yang H, Trinh K, Young JM, Kennedy, SR, Yamashita YM, Pallanck L & Malik HS. (2016). A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster. eLife 5: e16923 PMID 27481326
Harris KG, Morosky SA, Drummond C, Patel MR, Kim C, Stolz DB, Bergelson JM, Cherry S & Coyne CB. (2015). RIP3 regulates autophagy and is required for Coxsackievirus B3 infection of polarized intestinal epithelial cells. Cell Host and Microbe 18(2): 221-232 PMID 26269957
Patel MR, Loo YM, Horner SM, Gale M Jr & Malik HS. (2012). Convergent evolution of escape from hepaciviral antagonism in primates. PLoS Biology 10: e1001282. PMID 22427742
Recommended by Faculty of 1000.
Previewed by Sedwick C. (2012). War Archives: How some primates fought off ancient viruses. PLoS Biology 10(3): e1001285. PMID 22427744
Patel MR, Emerman M & Malik HS. Paleovirology – Ghosts and gifts of viruses past. Current Opinion in Virology Review 1(4): 304-9. PMID 22003379
Chia PH, Patel MR, Wagner OI, Klopfenstein DR & Shen K. (2013). Intramolecular regulation of presynaptic scaffold protein SYD-2/Liprin-α. Molecular and Cellular Neuroscience 56C: 76-84. PMID 23541703
Chia PH, Patel MR & Shen K. (2012). NAB-1 instructs synapse assembly by linking adhesion molecules and F-actin to active zone proteins. Nature Neuroscience 15: 234-242. PMID 22231427
Patel MR & Shen K. (2009). Neurite Extension: Starting at the finish line. Cell 137: 207-209. Preview. PMID 19379686
Patel MR & Shen K. (2009). RSY-1 is a novel local inhibitor of presynaptic assembly. Science 323: 1500-3. PMID 19286562
Previewed by Sigrist SJ. (2009) The yin and yang of synaptic active zone assembly. Sci Signal 2: pe32. PMID 19436057
Patel MR, Lehrman EK, Poon VY, Crump JG, Zhen M, Bargmann CI & Shen K. (2006). Hierarchical assembly of presynaptic components in defined C. elegans synapses. Nature Neuroscience 9: 1488-98. PMID 17115039